| Pair Name | Honokiol, Rosiglitazone | ||
| Phytochemical Name | Honokiol (PubChem CID: 72303 ) | ||
| Anticancer drug Name | Rosiglitazone (PubChem CID: 77999 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Honokiol, Rosiglitazone | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Expression | CCND1 | hsa595 |
| Down-regulation | Expression | CCNE1 | hsa898 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Expression | RB1 | hsa5925 | |
| In Vitro Model | Mahlavu | Hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0405 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Homo sapiens (Human) | CVCL_0525 | |
| Result | Honokiol combined with rosiglitazone showed more effective growth inhibition in hepatoma cells mediated through the regulation of G0/G1 phase-related proteins p21, cyclin D1, cyclin E1, and Rb and cell cycle progression | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells. J Chin Med Assoc. 2016 Aug;79(8):415-21. doi: 10.1016/j.jcma.2016.03.003. | Click |
